Should You Stop Taking Glucosamine Because of Alzheimer's Concerns?

Glucosamine has long been one of the most commonly used supplements for joint pain and osteoarthritis. Recently, headlines have raised concerns about a possible connection between glucosamine and Alzheimer's disease, leaving many people wondering whether they should stop taking it.

The short answer is: not necessarily.

What Did the New Research Find?

A recent study found that people who already had mild cognitive impairment (MCI) or dementia appeared to experience faster progression of their condition while taking glucosamine. Researchers believe glucosamine may affect certain pathways involved in how proteins are processed in the brain.

While these findings are important and deserve further study, it is equally important to understand what the study did—and did not—show.

The study found an association, meaning glucosamine use was linked to a higher risk of progression in certain patients. It did not prove that glucosamine caused Alzheimer's disease or dementia.

What Have Other Studies Shown?

Several large studies involving hundreds of thousands of participants have found very different results. Some reported no increased risk of dementia among glucosamine users, while others found that regular glucosamine use was associated with a lower risk of developing dementia.

Because the findings are conflicting, experts do not currently recommend that everyone stop taking glucosamine.

Should You Stop Taking It?

For most healthy adults taking glucosamine for joint pain, there is currently no strong evidence that the supplement causes Alzheimer's disease.

However, if you have:

• Mild cognitive impairment (MCI)

• Alzheimer's disease

• Another form of dementia

• Significant memory concerns

it may be worth discussing the risks and benefits with your healthcare provider.

Are There Any Other Risks?

Glucosamine is generally considered safe for most people. However, it can interact with certain medications, especially blood thinners such as warfarin, and may not be appropriate for everyone.

As with any supplement, it is important to let your healthcare provider know what you are taking so potential interactions can be reviewed.

The Bottom Line

At this time, the evidence does not support a recommendation for everyone to stop taking glucosamine. The newer study raises important questions, particularly for individuals who already have memory impairment, but additional research is needed before any definitive conclusions can be made.

If glucosamine is helping your joint pain and you are not experiencing side effects, it is reasonable to continue taking it while we learn more. If you have concerns about memory changes, Alzheimer's disease, or whether glucosamine is right for you, schedule an appointment so we can discuss your individual situation.

As always, treatment decisions should be personalized and based on your overall health, medical history, and goals of care.

Holly Hawks, FNP-BC, ARNPHolly Hawks Primary Care PLLC